My conclusion - as GWAS genetic scans expand in N and #genes, the "missing heritability" in narrow sense heritability is disappearing relative to earlier studies. To me, it is a misnomer to call the remaining difference between broad and narrow sense heritability "missing" since by definition, broad sense heritability includes gene-environment and the gene-gene interactions that you discuss.
Good exposition. I think about these same topics constantly, particularly as it pertains to neuroscience and psychiatry. It’s a big topic, and you’ve highlighted good contemporary resources.
"Missing heritability is substantial" - that depends on definitions.
ref 1 Wainschtein says ", we find that WGS captures approximately 88% of the pedigree-based narrow sense heritability"
I wrote an in depth piece addressing missing heritability: https://purescience.substack.com/p/missing-heritability-and-the-heritability?r=p3jgh
My conclusion - as GWAS genetic scans expand in N and #genes, the "missing heritability" in narrow sense heritability is disappearing relative to earlier studies. To me, it is a misnomer to call the remaining difference between broad and narrow sense heritability "missing" since by definition, broad sense heritability includes gene-environment and the gene-gene interactions that you discuss.
Good exposition. I think about these same topics constantly, particularly as it pertains to neuroscience and psychiatry. It’s a big topic, and you’ve highlighted good contemporary resources.