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Why Explaining Depression Is Difficult
New questions will provide new answers
Sep 8
•
Randolph Nesse
18
1
2
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Antidepressants are analgesics for mental pain
Much of the intense controversy that swirls around antidepressants arises from not understanding how they help.
Jul 9
•
Randolph Nesse
37
9
Overprescribing and the "Do Something Imperative"
The intense situation where decisions are made
Jun 6
•
Randolph Nesse
18
4
3
Runaway positive feedback and disease
Vicious cycles are everywhere once you recognize them
Jan 25
•
Randolph Nesse
18
9
4
The genotype-to-phenotype path is a maze in a tangled bank
Severely limiting the power of genetic predictions
Jan 6
•
Randolph Nesse
26
2
2
Psychiatry’s Holy Grail does not exist. What now?
We need a medical view of disorders as failure modes in functional systems
Dec 14, 2025
•
Randolph Nesse
42
7
9
Viewing Diseases As Adaptations
An error that is as natural as it is serious
Oct 14, 2025
•
Randolph Nesse
16
6
3
Mood disorders are control system failure modes
Not products of specific brain abnormalities
Sep 15, 2025
•
Randolph Nesse
55
1
13
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Randy Nesse's essays on why evolution left us vulnerable to sickness, suffering, and simplistic thinking.
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