Nessays

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Overprescribing and the "Do Something Imperative"
The intense situation where decisions are made
Jun 6 • Randolph Nesse
Runaway positive feedback and disease
Vicious cycles are everywhere once you recognize them
Jan 25 • Randolph Nesse
The genotype-to-phenotype path is a maze in a tangled bank
Severely limiting the power of genetic predictions
Jan 6 • Randolph Nesse
Psychiatry’s Holy Grail does not exist. What now?
We need a medical view of disorders as failure modes in functional systems
Dec 14, 2025 • Randolph Nesse
Viewing Diseases As Adaptations
An error that is as natural as it is serious
Oct 14, 2025 • Randolph Nesse
Mood disorders are control system failure modes
Not products of specific brain abnormalities
Sep 15, 2025 • Randolph Nesse
Epistasis Illustrated
to make the concept and formulas make sense
Sep 7, 2025 • Randolph Nesse
ADHD is not an adaptation
But foraging theory is crucial for understanding it
May 26, 2025 • Randolph Nesse
Nessays
Nessays
Randy Nesse's essays on why evolution left us vulnerable to sickness, suffering, and simplistic thinking.
Recommendations
Eric Turkheimer - Gloomy Prospect Blog
Eric Turkheimer - Gloomy Prospect Blog
Eric Turkheimer

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